What GHK-Cu Is
GHK-Cu is the copper-coordinated form of the human tripeptide GHK (Glycyl-L-Histidyl-L-Lysine). The free tripeptide is a 340 Da molecule found naturally in human plasma; concentrations decline notably with age. When GHK binds a divalent copper ion (Cu²⁺), it forms the GHK-Cu complex.
The Copper Coordination
The histidine and lysine residues coordinate the copper ion through their nitrogen atoms, forming a stable complex. The blue color of GHK-Cu solutions in research vials comes from this copper coordination — it is a visible signature of the intact complex. Loss of the blue color suggests the copper has dissociated.
Research Timeline
GHK was first isolated and characterized in 1973 by Loren Pickart. The copper-binding properties were documented shortly after, and the complex has been studied across various research models since the 1980s — primarily in dermatology, wound research, and copper biology contexts. The body of literature is substantial relative to most research peptides.
Formulations in the VialPepLab Catalog
We offer GHK-Cu in two formats:
- 50 mg lyophilized vial — for reconstitution and research applications
- 100 mg lyophilized vial — for extended research protocols
- Copper Peptide Topical Serum — pre-formulated 30 mL serum for topical research applications
All formats are verified for purity by HPLC and for copper content via ICP-MS or equivalent atomic analysis. See COAs in the COA Library or browse the Anti-Aging & Skin category for all formulations.
Storage Note
GHK-Cu in lyophilized form is stable at -20 °C, protected from light. After reconstitution, the complex is light-sensitive — store in amber vials or opaque containers, refrigerated. Loss of the characteristic blue color indicates degradation and reduced research utility. See full storage protocols.
For broader context on regeneration peptides, see the pentadecapeptide family comparison.